How to use Technologies offered

A search for a cancer, preclinical stage, synthetic opportunity would use the selection "Therapeutics, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.

Selection of 'Enabling Technology, Platform Technology' in 'Sector' will identify all kinds of research technologies that can be used in more areas of life sciences than pharmaceuticals only.

Each technology profile gives the name of a company or academic institute as source of the offer, and a link allowing to contact the potential licensor. In most cases a profile includes a pdf covering the available non-confidential information as well as detailed contact data.

Registered users can create non-public notifications profiles which will inform them about new 'Technologies Offered' entries fitting their needs as specified. In addition these profiles allow them to filter the available information more comfortably.


Anti-tuberculosis drug

Organization name

PROvendis GmbH


Tuberculosis resulting from infection with Mycobacterium tuberculosis (Mtb) is a serious global health problem accounting for 1.7 million deaths in 2016. A major reason for the high morbidity and mortality caused by Mtb is the long duration of therapy and increasing multidrug-resistance of Mtb strains.

Mtb has been treated with combination therapy for over fifty years. Yet according to the latest WHO statistics, approximately half a million new cases of multidrug-resistant tuberculosis are diagnosed every year. Of these, it is estimated that approximately 40,000 have extensively drug-resistant tuberculosis.

In view of these numbers, there is a medical need for new anti-Mtb compounds to overcome resistance to known drugs in patients.

The inventors were able to demonstrate that lansoprazole and derivatives thereof exhibit growth inhibiting properties against intracellular Mtb. In particular, it has been proven that the reduced form lansoprazole sulfide is the active moiety. Yet, lansoprazole is not metabolized in a sufficient amount to serve as a prodrug. Thus, the inventors propose lansoprazole sulfide (LPZS) as a new drug to treat Mtb infections.

Commercial Opportunities

LPZS is a promising lead-compound which is distinct from substances identified in other TB-drug screens since its backbone structure has been an approved over-the-counter drug for the past 30 years. Thus, the finding may benefit from 40 years of intense research on pharmacological properties of PPI-benzimidazole analogues and an extensive production pipeline maintained by several pharmaceutical companies. On behalf of University of Cologne, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.

Competitive Advantages

  • Active against multidrug-resistant tuberculosis
  • Small molecule
  • Tested in-vitro and in-vivo
  • SAR data available

Current Status

Patents have been filed for EP and USA based on WO 2016/120259 A1. Efficacy has been proven in-vitro and in a mouse model of Mtb infection. Preliminary SAR data are available.

Relevant Publications

Rybniker, J. et al. (2015) Lansoprazole is an antituberculous prodrug targeting cytochrome bc1. Nat Commun. 6:7659

Subtil, F. et al. (2018) Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing. Int. J. Antimicrob. Agents 51(3 ): 378–384.

To view the contact information, attachments and url of this profile you have to login into your account or register a new account: Login Register

Your feedback to "Anti-tuberculosis drug"


latest entries

latest entries