How to use Technologies offered

A search for a cancer, preclinical stage, synthetic opportunity would use the selection "Therapeutics, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.

Selection of 'Enabling Technology, Platform Technology' in 'Sector' will identify all kinds of research technologies that can be used in more areas of life sciences than pharmaceuticals only.

Each technology profile gives the name of a company or academic institute as source of the offer, and a link allowing to contact the potential licensor. In most cases a profile includes a pdf covering the available non-confidential information as well as detailed contact data.

Registered users can create non-public notifications profiles which will inform them about new 'Technologies Offered' entries fitting their needs as specified. In addition these profiles allow them to filter the available information more comfortably.


Collagen for bone regeneration

Organization name

PROvendis GmbH


Destruction of bone tissue after accidents, infections or tumor therapy requires a highly orchestrated regeneration process dependent on the presence of osteoblasts forming new bone. Since native bone harbors too few osteoblasts to enable a fast recovery of acutely injured bone tissue, stem cells need to give rise to new osteoblasts directly upon fracture or surgical treatment. In this regard, mesenchymal stem cells (MSCs) are commonly described to undergo differentiation into osteogenic cells types, such as osteoblasts.

Collagen is a natural part of the bone composition, and collagen membranes are in use to support bone regeneration. However, these membranes are based on collagen, which is completely dissolved before it is further processed to a membrane, and consequently has completely lost its natural structure and consequentyl some important biological functions. Researchers of the University of Bielefeld have found a method to prepare collagen type I in its natural pore-like structure. They have shown that cultivation of human inferior turbinate stem cells (ITSCs) on collagen fibrils prepared by that method show osteogenic differentiation. Therefore, this collagen preparation method can be used for multiple applications in regenerative medicine, e.g. in bone fractures after accidents, joint replacement, dental prothesis, or plastic surgery.

Commercial Opportunities

The invention is offered for licensing and further development.

Competitive Advantages

  • Support of osteogenic stem cell differentiation in regenerative medicine
  • Eligible to multiple applications in bone regeneration

Current Status

In case of interest we are pleased to inform you about the patent status. In vivo experiments are ongoing.

Relevant Publications

Schürmann, M., et al. (2014) Interaction of adult human neural crest-derived stem cells with a nanoporous titanium surface is sufficient to induce their osteogenic differentiation. Stem Cell Research 13(1): 98-110.

To view the contact information, attachments and url of this profile you have to login into your account or register a new account: Login Register

Your feedback to "Collagen for bone regeneration"


latest entries

latest entries