How to use Technologies offered

A search for a cancer, preclinical stage, synthetic opportunity would use the selection "Therapeutics, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.

Selection of 'Enabling Technology, Platform Technology' in 'Sector' will identify all kinds of research technologies that can be used in more areas of life sciences than pharmaceuticals only.

Each technology profile gives the name of a company or academic institute as source of the offer, and a link allowing to contact the potential licensor. In most cases a profile includes a pdf covering the available non-confidential information as well as detailed contact data.

Registered users can create non-public notifications profiles which will inform them about new 'Technologies Offered' entries fitting their needs as specified. In addition these profiles allow them to filter the available information more comfortably.

Name

Biomarkers for Diagnosis and Therapy of Pulmonary Hypertension offered by University of Frankfurt

Organization name

INNOVECTIS Gesellschaft für Innovations-Dienstleistungen mbH

Profile

Abstract

The present invention relates to the use of biomarkers sFlt and PlGF for diagnosis, early recognition and risk stratification of pulmonary hypertension.

Background

Pulmonary hypertension (PH) is a serious progressive disease, which - if untreated - leads to death within few years. A characteristic of PH is an increasing blood pressure within pulmonary circulation which is linked to an progressive insufficiency of the right heart. So far, diagnosis of PH is based on echocardiography of the right heart as non-invasive method or on the biomarker BNP. Still recently, it has been shown that BNP is suitable to only a limited extent.

Invention

Scientists of the University Medical Schools of Frankfurt/Main and Giessen and from Kerckhoff-Klinik in Bad Nauheim performed a clinical trial involving 256 patients showing that biomarkers sFlt and PlGF are highly specific for diagnosis of PH. Patients with PH of different etiology (IPAH, APAH, PAH linked with COPD or fibrosis, CTEPH, PVAH) were included in this study. Hemodynamic parameters and blood levels of sFlt and PlGF have been observed over a period of one year. Statistical analysis showed a high test accuracy for diagnosis of sFlt and PlGF by using determined cut-off values. Meanwhile, the results of the initial study have been validated by a second trial.

Application

Preferred is an immunologic test (ELISA) for the determination of blood level of sFlt and PlGF in patients. On the basis of blood level of sFlt and PlGF, diagnosis or monitoring of treatment or the risk for occurrence of PH is possible.

Customer Benefits

  • The novel biomarkers enable a diagnosis of PH with higher sensitivity and specificity than currently available biomarkers.
  • The novel biomarkers simplify early recognition and monitoring of treatment of PH. They might close the gap between echocardiography of the right heart as non-invasive method on the one hand and invasive methods on the other hand.

Project Status

A priority German patent application has been filed (DE 10 201 013 555). The PCT procedure was initiated (WO 2011/121075).

Owner of the patent application are University of Frankfurt am Main, University of Giessen and three free inventors.

Licensing or assignment of the technology is possible as well as cooperation for further development of the invention.

To view the contact information, attachments and url of this profile you have to login into your account or register a new account: Login Register

Your feedback

Please click here to log in to view the complete profile.

 
 

latest entries