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A search for a cancer, preclinical stage, synthetic opportunity would use the selection "Therapeutics, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.
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Researchers at the University of Heidelberg have synthesized several ferrocene derivatives that are expected to treat cancer.
They act as prodrugs with improved characteristics and have been successfully tested in living cancer cell lines.
Their mode of action namely the increase of the ROS levels and the simultaneous suppression of the antioxidative system of the cancer cell offers broad therapeutic application.
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