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Glycopeptides Synthesis Services

Organization name

Creative Peptides


Glycopeptide has been widely recognized as peptide that contains carbohydrate moieties (glycans). Due to the nature linkage between glycan and the amino acid residues of peptide, glycopeptides can be classified into three types: N-linked, O-linked and C-linked glycopeptides. Among of them, N-linked glycopeptides are the most common type in nature, which N is referred to the asparagine that attached by the glycan. Glycan of O-linked glycopeptides is commonly linked to the hydroxyl groups of serine and threonine, while sometime also bond to lysine, proline and tyrosine. While the least common C-linked glycopeptides are recognized as the attachment between mannose and tryptophane.

Glycopeptides, especially the glycan chains, have played pivotal roles in various biological activities and involved in numerous biological recognition events, such as immune system, endocrine system, protein folding and cell communication.

In recently years, more and more attention has been focused on the function of glycopeptides in immunology realm. It is well-known that a majority of key molecules, which involved in innate and adaptive immune response, and some secondary metabolites produced by microorganism are all glycoeptides. And the glycosylation of immunoglobulins plays key roles in the regulation of immune reactions: glycans located at various sites modulate a diversity of immunoglobulin properties, including protein conformation, stability, serum half-life and binding affinity. In the meantime, changes in glycans or glycopeptides may also be involved in a variety of human immune-related diseases, such as rheumatoid, autoimmune disease, Wiskott-Aldrich syndrome, infection disease and even cancer. In this way, synthetic glycopeptides have provided a unique frontier for the investigation and better understanding in both glycobiology and proteomics, and also contribute to the development of either biotechnological or therapeutic applications.

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