How to use Technologies offered

A search for a cancer, preclinical stage, synthetic opportunity would use the selection "Therapeutics, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.

Selection of 'Enabling Technology, Platform Technology' in 'Sector' will identify all kinds of research technologies that can be used in more areas of life sciences than pharmaceuticals only.

Each technology profile gives the name of a company or academic institute as source of the offer, and a link allowing to contact the potential licensor. In most cases a profile includes a pdf covering the available non-confidential information as well as detailed contact data.

Registered users can create non-public notifications profiles which will inform them about new 'Technologies Offered' entries fitting their needs as specified. In addition these profiles allow them to filter the available information more comfortably.


in vivo validated targets for diagnosis, treatment and prevention of JAK/STAT associated diseases

Organization name

DKFZ Deutsches Krebsforschungszentrum



This technology relates to a screening method to identify new modulating compounds (small molecules, biologicals, etc.) for JAK/STAT associated diseases. The JAK/STAT signaling cascade represents an important pathway whose roles includes cell proliferation, haematopoiesis and immune response.

The Technology

Inventors from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Max-Planck-Institute for Biophysical Chemistry, Goettingen have developed a screening technology wherewith the activity of the Drosophila JAK/STAT signal transduction pathway can be measured in Drosophila Kc cells.

In order to identify novel pathway components and to widen classical genetic screens, the inventors have undertaken a genome-wide RNA interference (RNAi) screen and analysed 20,026 RNAi-induced phenotypes in cultured Drosophila melanogaster haemocyte-like cells.

With this screening technology the researchers have succeeded in identifying several genes with strong human homologues, which are associated with human malignancies. These new, in vivo validated targets enable the identification of JAK/STAT modulators for diagnosis, treatment and prevention of JAK/STAT associated diseases.

Key facts

  • Technology to identify new targets in the JAK/STAT pathway
  • Method for identifying JAK/STAT-modulating compounds
  • Several novel human targets of the JAK/STAT pathway associated with human diseases identified

Development Stage

Analysis of 20,026 RNA interference (RNAi)-induced phenotypes in cultured Drosophila melanogaster haemocyte-like cells identified interacting genes encoding 4 known and 86 previously uncharacterized proteins.

Subsequently, cell-based epistasis experiments were used to classify these proteins based on their interaction with known components of the signalling cascade. In addition to multiple human disease gene homologues, the inventors have found the tyrosine phosphatase Ptp61F and the Drosophila homologue of BRWD3, a bromo-domain-containing protein disrupted in leukaemia. Moreover, in vivo analysis demonstrates that disrupted dBRWD3 and overexpressed Ptp61F function as suppressors of leukaemia-like blood cell tumours.

Applications and Commercial Opportunity

The screen represents a comprehensive identification of novel loci required for JAK/STAT signalling and provides molecular insights into an important pathway relevant for human cancer. Human homologues of identified pathway modifiers may constitute targets for therapeutic interventions.


Michal Boutros (DKFZ), Martin Zeidler (MPI Göttingen), Patrick Müller (MPI Göttingen)

Intellectual Property

International PCT patent application published as WO2006/133931. Subsequent European (EP1910539) and USA (US-2009-0186815) equivalent filed. DKFZ is seeking for an industrial partner to license this technology or to collaborate with DKFZ.

To view the contact information, attachments and url of this profile you have to login into your account or register a new account: Login Register

Your feedback

Please click here to log in to view the complete profile.


latest entries