IntraCellular Delivery System(ICDS™)
Therapeutic protein drugs are an important class of medicines most in need of novel therapies. Recently approved recombinant protein therapeutics have been developed to treat a wide variety of clinical indications, including cancers, autoimmunity/inflammation, exposure to infectious agents, and genetic disorders. However, the failure of proteins to penetrate mammalian cells or target tumor cells restricts their value as therapeutic tools in a variety of diseases. Unlike small molecules, a peptide or a protein is normally difficult enter into intact cells due to the cell membrane's semipermeability nature.
Creative Peptides offer ICDSTM-NH2-kit containing good carriers that can easily cross cell membranes. ICDSTM-NH2-kit considered as useful tools to assist the transshipment of peptide or protein from outside to the inside of cells. It provides a convenient way to deliver your bioactive proteins into cells by conjugating them with ICDSTM peptides. This ICDSTM-NH2-kit can be used with a wide range of molecule up to 150kDa. In order to verify its effectiveness, Creative Peptides’ scientists have tested ICDSTM-NH2-kit using a wide variety type of cells, such as SkBr3, HEK293 and CHO, and nearly all of the tests have the positive results.