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Name

Liposomal Clodronate as a Therapy for Auto-immune Hemolytic Anemia

Organization name

National Jewish Health clinical and research institution

Profile

Summary

This invention is using liposomal clodronate as a therapy for auto-immune hemolytic anemia.

Potential Applications

  • Therapy for auto-immune hemolytic anemia
  • The therapy is applicable to both humans and companion animals

Advantages of Invention

  • The method is less invasive than surgery (splenectomy)
  • Decrease use of steroids
  • Decrease side effects

State of Development

  • The efficacy of this therapy has been demonstrated by some strong in vivo data obtained in mice.
  • Using a mouse model in which animals were given anti red blood cell antibodies, treatment with liposomal clodronate substantially decreased red blood cell destruction.
  • In addition, this effect was detected within hours and lasted at least a week.

Further R&D Required

Additional in vivo studies with other animal models.

Licensing Potential

Available for licensing.

Patent Status

U.S. Patent # 7,090,865

Inventors

  • Mike Jordan, MD, Philippa Marrack, PhD and John Kappler, Ph

Publications

Jordan et al. (2003) Blood: 101(2): 594-601
Mathes et al. (2006) Exp Hemat; 34:1393-1402  

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