How to use Technologies offered

A search for a cancer, preclinical stage, synthetic opportunity would use the selection "Therapeutics, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.

Selection of 'Enabling Technology, Platform Technology' in 'Sector' will identify all kinds of research technologies that can be used in more areas of life sciences than pharmaceuticals only.

Each technology profile gives the name of a company or academic institute as source of the offer, and a link allowing to contact the potential licensor. In most cases a profile includes a pdf covering the available non-confidential information as well as detailed contact data.

Registered users can create non-public notifications profiles which will inform them about new 'Technologies Offered' entries fitting their needs as specified. In addition these profiles allow them to filter the available information more comfortably.


Method for direct formamide or acetamide formation of adamantane derivatives

Organization name

TransMIT Gesellschaft für Technologietransfer mbH



This invention offers a new method for the direct and halogen-free formamide or acetamide formation of adamantane. Until now, the synthesis of amidoadamantanes have the disadvantage that halogen-containing by-products are formed, whose disposal is laborious and costly.


The adamantane modifications are chosen to enhance lipophilicity and stability of drugs, thereby improving their pharmacokinetics. Amido- and amino admantane derivatives can be used as drug delivery systems. They are able to overcome the blood-brain barrier and are competent to penetrate into the fatty tissue.

Due to these properties adamantane derivates are already used as therapeutics (e.g. for neurodegenerative diseases) and cosmetics. They are, for example, used as antiviral drugs or to treat Parkinson’s as well as Alzheimer’s diseases.


The method is not only distinguished by the absence of halogens, but also comprises a more favorable impurity profile. Even an in-situ production of the starting materials from inexpensive precursors is possible, so that the desired products are available in a one-pot fashion.


Organonitrogen compounds that are used as biocides include anilides, amines, amides, nitroparaffins, biguanides, triazines, ureas, hydantoins and a large variety of adamantane derivatives. Organonitrogen biocides are used in cooling systems, secondary oil recovery and as preservatives in cosmetics, toiletries, pharmaceuticals, and veterinary products. In 2006 organonitrogen biocides accounted for sales of 117,7 Mio US-Dollar in Europe with a growth rate of 3,8%.

To view the contact information, attachments and url of this profile you have to login into your account or register a new account: Login Register

Your feedback

Please click here to log in to view the complete profile.


latest entries