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Modulation of ß-Catenin signalling for the treatment of cardiovascular diseases

Organization name

ascenion GmbH



ß-catenin, one of the key regulator molecules of Wnt signalling pathway has been described within several clinical syndromes like cancer diseases.


The present technology provides ß-catenin as a target in cardiovascular diseases. In vivo data derived from transgenic mouse models indicate a hypertrophy and enforcement of myocard action indicating a therapeutic use in cardiac repair upon nuclear depletion of ß-catenin.

Commercial Opportunity

In-licensing of know-how and IP for target and validation, (pre-)clinical testing and development of therapeutics.

Patent Situation

A priority establishing European Patent is pending (confidential).

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