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Name

Multisite complex enhancing vaccination against Staphylococcus aureus

Organization name

Interface Entreprises-Université de Liege

Profile

The University of Liège in Belgium has developed new scaffolds based on a protein carrier which, as an adjuvant, increase the vaccinal efï¬Âcacy and neutralize virulence factors of S.aureus.    

As the actual treatments are more and more faced with resistant strains and multiple virulenceʼs factors responsible of the toxicity, there is indeed a need of alternative treatments of S.aureus.    

The University of Liège is seeking companies interested in a development collaboration or in-licensing opportunity for this novel complex which induces immune response against this bacteria.         

Advantages

  • targets simultaneously major virulence factors for an increased vaccinal effect (Immunization >60-70%);      
  • while due to its structure it can be easily added to vaccinal preparation
  • can be produced in high amount which reduces production costs.          

Potential Applications    

The scaffolds may be used as antigenic source in any vaccinal preparations, for example against S.aureus.              

Features   

This protein carrier developed from anattenuated virulence factor :

  • allows to target simultaneously several virulence factors (included the protein carrier) involved in the different infection steps by S.aureus;      
  • leads to the production of antibodies which increase the bacteria coating and block the biological activity of the virulenceʼs factors;                            
  • gives high puriï¬Âcation yields;                
  • induces also immune reactions against short;                  
  • is organized in nanostructure.                                                      

Patent Status            

Pending : WO2010081875A1                                     

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