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Name

New Genetic Test for Shar-Pei Autoinflammatory Disease (SPAID)

Organization name

MBM ScienceBridge GmbH

Profile

SPAID is a spontaneously occurring autoinflammatory disease in Shar-Pei dogs. It is characterized by recurrent signs of inflammation like fever, swollen joints, reddened skin, ear problems, arthritis. SPAID can even lead to amyloidosis and kidney failure. The dogs with SPAID may experience one or more of these problems.

Challenge

SPAID is a severe genetic disease in Shar-Pei which cannot be cured and results in serious and persistent signs in affected dogs. Without the knowledge of the pathomechanism of the autoinflammatory process, therapeutic options cannot be developed.
The previously offered genetic testing method for an SPAID-associated mutation is a complex and expensive procedure and does not provide a functional explanation for disease development.

Our Solution

Scientists at the University of Veterinary Medicine Hannover developed a new genetic test for a functional mutation
which triggers SPAID in Shar-Pei dogs. Variant detection is performed using a cost-effective detection method and
thereby provides an efficient tool for breeders to do genetic testing for SPAID in their dogs to enable targeted
breeding decisions.

Advantages

  • Identification of a new genetic test responsible for SPAID.
  • Genetic variant can be detected using simple and inexpensive method.
  • Dogs can be tested at any age.
  • Confidence and assurance for dog breeders for targeted breeding decisions.

Applications

Genetic test for SPAID predisposition in Shar-Pei (diagnostics).

Developmental Status

The genetic test has been successfully tested and validated for Shar-Pei EDTA-stabilized blood samples.

Patent Status

A European patent application has been filed (Applicant: University of Veterinary Medicine Hannover, Foundation, Germany).

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