How to use Technologies offered

A search for a cancer, preclinical stage, synthetic opportunity would use the selection "Therapeutics, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.

Selection of 'Enabling Technology, Platform Technology' in 'Sector' will identify all kinds of research technologies that can be used in more areas of life sciences than pharmaceuticals only.

Each technology profile gives the name of a company or academic institute as source of the offer, and a link allowing to contact the potential licensor. In most cases a profile includes a pdf covering the available non-confidential information as well as detailed contact data.

Registered users can create non-public notifications profiles which will inform them about new 'Technologies Offered' entries fitting their needs as specified. In addition these profiles allow them to filter the available information more comfortably.

Name

New highly specific and sensitive marker for adenocarcinomas of the lung

Organization name

Ascenion GmbH

Profile

Challenge

Lung Cancer is one of the leading causes of death worldwide with a still rising incidence and differentiation between Small Cell Lung Cancer (SCLC) and Non Small Cell Lung Cancer (NSCLC) is of large therapeutic relevance. Novel chemo-therapeutic approaches have recently been developed for NSCLC, which is known as a largely chemo-resistant tumor group. Clinical studies revealed substantial differences as to the adequate therapeutic regimens of the three main types of NSCLC (adenocarcinomas versus squamous cell carcinomas and large cell carcinomas), but existing markers for required sub-differentiation (TTF-1, SP-A, SP-B) either lack sensitivity or specificity. Therefore, novel markers for a reliable sub-differentiation of NSCLC are needed.

Technology

The new MadL monoclonal antibody was raised against human alveolar epithelial cells type II, and is a highly specific marker for adenocarcinomas of the lung. In addition, it specifically detects alveolar epithelial cells type II and alveolar macrophages. The antibody can be used for the analyses of native, formalin fixed or HOPETM-fixed tissue.

Commercial Opportunity

The technology is offered for in-licensing for the development of a diagnostic kit.

Developmental Status

In a large scale study comprising 280 specimens, the sensitivity and specificity of the MadL antibody was analysed and compared with established markers (TTF-1, SP-A, SP-B). MadL displays >99% specificity for adenocarcinomas of the lung (TTF-1: 88%). In addition, MadL has a much higher sensitivity (74%) as compared to the established highly specific markers (SP-A: 55%, SP-B: 53%). The MadL antibody has successfully been used as an additional marker for adenocarcinomas in routine analysis of clinical specimens for the last two years.

To view the contact information, attachments and url of this profile you have to login into your account or register a new account: Login Register

Your feedback

Please click here to log in to view the complete profile.

 
 

latest entries