New implant coating preventing biofilm-formation
An aging population that maintains an active lifestyle will inevitably lead to increasing number of bone injuries and a corresponding need for adequate implants and prostheses. One of the most severe problems in this context is the colonization of implant surfaces with antibiotic-resistant bacterial biofilms. Implants with antibiotic activity can locally achieve highly efficacious local concentrations without adverse systemic effects and are therefore under intense investigation. However, most approaches suffer from adverse side effects, such as inadequate stability, temporally limited activity or inflammatory tissue responses against polymeric coatings. This lack of appropriate solutions calls for novel approaches including antibacterial implant coatings that do not contain organic polymeric substances. Moreover, in the light of potential age-related bone deficiencies it would be of advantage if the implant would additionally facilitate bone healing.
The invention relates to “controlled release coatings” for medical applications (e.g. implants and prostheses) consisting of Layered Double Hydroxides (LDH) including bivalent and trivalent metal cations and anions. LDHs containing Mg(OH)2 were loaded with antibacterial drugs and were demonstrated to be highly efficacious against biofilms of the pathogen P. aeruginosa. Mg(OH)2 could promote calcium phosphate deposition and bone formation. Accordingly, these inventive coatings can provide the necessary medical preconditions for successful use in orthopedics for bone healing or for bone replacement prostheses.
The technology may be explored for orthopedic medical applications and is offered for co-development or in-licensing.
First in vivo results obtained in a suitable mouse model for bone and cartilage implants.
German patent application filed in 2010 (DE 102010036039). International application (PCT/EP2011/004376) filed in August 2011.