New tripeptides for reducing oxidative stress, prevent photoaging
Oxidative stress plays a major role in both intrinsic and extrinsic aging of the skin since reactive oxygen species (ROS) are generated in the process of normal cellular metabolism or by physiological processes and, in addition, are produced in particular by the UVA component but also by the UVB component. If not suppressed upon formation, ROS have far-reaching effects on the integrity of all cellular bio-molecules such as DNA, protein and lipids with regard to UV-induced aging of the skin. Thus, science is searching for strategies for preventing photoaging.
The present invention relates to the use of three tripeptides for the reduction of oxidative stress.
The tripeptides are particularly useful for the treatment of a disease or damage caused by oxidative stress, such as vitiligo and scleroderma; furthermore, a disease or damage of the hair, like premature hair loss or premature formation of grey hair can also be treated.
The invention also relates to the cosmetic use of the tripeptides, in particular against skin aging.
According to the present invention, the compounds are to be used as an active compound for the production of a pharmaceutical composition for the treatment of a disease or damage caused by oxidative stress. The treatment may be a prophylactic or therapeutic treatment.
The modulating effect of the three tripeptides was examined inter alia on human dermal fibroblasts. All three tripeptides could suppress UVA-induced intracellular accumulation of oxidative stress in a significant way.
New aspects of the invention
New compositions comprising at least one of the three tripeptides of the invention and effective strategies for their therapeutic and cosmetic use for reducing oxidative stress.
Advantages of the invention
Small peptides (tripeptides) which can be used for the reduction of oxidative stress (both therapeutic and cosmetic use).
A European and PCT patent application have been filed.