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Name

Ultra-sensitive Cytokine Detection from Chimera Biotec

Organization name

Chimera Biotec

Profile

Ultra-Sensitive Cytokine Detection

Biomarker for inflammatory diseases like cytokines are a challenging target for ligand binding assays. A major goal in current drug development includes specific screening of individuals based on there citokine baseline levels. Chimera Biotec offers ultra-sensitive immunoassay development based on the proprietary Imperacer (Immuno-PCR) platform. Biomarker quantification in the sub pg/ml concentration level becomes possible.

Challenge

Around 70 per cent of failed clinical trials are predominantly related to

  • unknown endogenous baseline level of target cytokine
  • undetectable drug-target-complex formation
  • limited data in drug efficacy testing with most commonly used ligand-binding technologies

Solution

The success of future clinical trials can be significantly increased with more precise and reliable target quantification

  • Determine baseline cytokine levels in healthy control individuals
  • Quantify biomarker concentrations in diseased population and generate data regarding a cut off point
  • detect anti-cytikine drug efficacy in complex formation with biomarker target
  • analyse change in biomarker concentration mediated by applied drug dose

Our Offer

Chimera Biotec offers customized immunoassay developments in the basis of the immunoPCR technology Imperacer®. The ultra sensitivity of the Imperacer technology enables biomarker analysis along the entire study course.

Please contact us if you would like to know more about the Imperacer® technology. We will be happy to assist you with your cytokine detection challenge.

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