How to use Technologies searched

A search for a company looking for a cancer, preclinical stage, synthetic opportunity would use the selection "Biomedicine, Diagnostics" in 'Sector', 'Cancerous, neoplasmatic' in 'Disease Category', 'Drugs, Small Molecule' in 'Technology' and 'Preclinical' in 'Development Stage'.

Selection of 'Enabling Technology, Platform technology' in 'Sector' will identify all kinds of searches for technologies that can be used in more areas of life sciences than pharmaceuticals only.

Each search profile gives the name or a short description of the company behind the search, and a link allowing to contact your potential licensee.

Registered users can create non-public notifications profiles which will inform them about new Technologies Searched entries fitting their expertise as specified. In addition these profiles allow them to filter the available information more comfortably.

Name

Lilly is looking for opportunities in Technologies

Organization name

Global External Research & Development Lilly Research Laboratories Eli Lilly and Company

Profile

Technologies

The vision at Lilly Research Laboratories, of which Global External R&D is a part, is a commitment to discovering, developing and acquiring innovative medicines to improve outcomes for individual patients.

The mission of Global External R&D New Technologies is to identify and objectively assess external opportunities according to Lilly's strategic needs in order to enable informed investment decisions and robust implementation plans, while building a relationship with their potential partners. Global External R&D New Technologies will partner effectively in managing both the exchange of information and business processes to deliver high quality, cost-effective, improved outcomes for patients.

Drug discovery functional areas:

  • Discovery Chemistry
  • IT / Informatics
  • Quantitative and Integrative Biology
  • In vivo Pharmacology
  • Drug Disposition and Toxicology
  • Pharmaceutical Development
  • Drug Delivery Systems

Technology needs:

Biotherapeutics
  • PET-labeling of proteins
  • Half-life extension of antibodies, peptides and proteins
  • Yeast expression and production systems
  • Antibody Fab production systems
  • Early identification of high expressing cell lines
  • Glycosylation technologies
  • Bi-specific/ multi-functional technologies: mAb/ alternative scaffolds
  • Peptide chemistry space: semi-synthetic, recombinant and conjugation chemistry
  • Site-Specific Chemical Modification of Protein Research: PEG replacement technologies
Biology
  • Biomarkers (identification → validation → assay development → commercialization)
  • Clinically annotated human tissues and biobanks
  • In vivo delivery of shRNAi
  • Development of in vivo imaging reagents
  • Stem cells as drug discovery tools
  • Mechanism of Action Assays for Kinases
  • Fragment-Based Screening
  • Antibodies (phosphor-antibodies) for monitoring cell signaling
  • Outsourcing:
    • “Omics” data generation and analysis
    • Quantitative mass spectrometry assays
    • Protein expression and purification
Neuroscience
  • Predictive biomarkers of any nature (e.g., genetic, proteomics, metabolic, other biochemical, biological, morphological
  • Predictive animal models
  • Ion channel Technologies
IT/Informatics
  • in vitro data analysis tools
  • Translational informatics
  • Data integration
  • Genetic data management
  • Collaboration technologies
  • Semantic Web technologies
  • Text analytics
Drug Delivery
  • Molecule and particle engineering technologies
  • Novel/ novel drug combinations in Oncology
  • Long-acting (extended release) molecule and formulation technologies
  • Delivery devices (novel parenteral delivery concepts and alternative delivery routes)
  • Oral modified release — new concepts
  • Nanomedicines and pharmaceutical nanodelivery technologies
  • Targeted delivery technologies
  • Drug delivery manufacturing technologies
Product Development
  • Bioprocess Development
    • Protein expression / production technology
    • Cell culture
    • Purification processes
  • Formulation design
    • BBB: Delivering large proteins to the brain
    • Economical, scaleable formulations
  • Packaging
    • Engineering
    • Improved barrier materials
    • Improved process for barriers (sealing, forming, etc.)
  • Small scale process modeling
  • Manufacturing
    • Green Chemistry
    • Reducing costs of CT Manufacturing
  • Adaptive clinical trial design
  • Predicting Crystallization
  • Patient Center-Product Design
    • Compliance Technologies (including Packaging)
    • Innovation to meet needs of special groups (i.e. elderly, handicap)
    • Tailored Therapeutics
Discovery
  • Novel biomarkers to determine efficacy/drug response to therapies, patient population stratification, PK-PD relationships, safety monitoring, and acceleration of clinical trials
  • Predictions of human PK and drug-drug interactions from in vitro results (disease state modeling)
  • Transporters: robust and sensitive substrate and inhibitor assays of the clinically significant uptake and export transporters
  • Immunohistochemistry: Tissue distribution of targets and using antibodies as pharmacodynamic markers of target activation/inhibition
  • Predictive Animal Models
  • High throughput and quantitative imaging technologies for drug development
  • Clinically annotated human tissues and biobanks

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